Heart Rate Variability in Adults with Sickle Cell Anemia During a Multitasking Field Test

Background: The integrity of the autonomic nervous system (ANS) is essential for keeping physiological processes stable, even under stress. Since there growing interest in heart rate variability (HRV) analysis noninvasive assessment ANS sickle cell anemia (SCA) patients, we studied behavior presence a stressor that simulates daily-life multitasking, Glittre ADL test (GA-T). Objectives: To evaluate involvement using HRV adults with SCA during GA-T and to quantify strength correlation lung muscle functions. Methods: In this cross-sectional study, 16 12 healthy controls without disease underwent GA-T, pulmonary function tests (spirometry, diffusing capacity carbon monoxide (DLCO), respiratory testing). Peripheral [handgrip (HGS) quadriceps (QS)] were also measured. Results: Compared controls, showed lower HRV, worse parasympathetic modulation due reductions following indices: root-mean-square difference successive normal iRRs (iRR) (RMSSD); percentage pairs consecutive whose > 50 m (pNN50); high-frequency component (HF); standard deviation instantaneous beat-to-beat (SD1) (P < 0.001 all). individuals greater sympathovagal imbalance (higher ratio between low-frequency HF components) complexity (lower approximate entropy). time was correlated activity RMSSD (rs = -0.650, P 0.01); pNN50 -0.932, 0.0001), -0.579, 0.01), SD1 -0.814, 0.0001). Correlations indices DLCO, HGS, QS measures significant. Conclusions: Adults have low activity, imbalance, abnormal complexity. addition, associated longer time, impairment diffusion, dysfunction.